Silantes uses a new technology to produce biomolecules such as amino acids, nucleotides, peptides, proteins and DNA labeled with the stable isotopes 2H and 13C and 15N.
Silantes employs staff of highly skilled scientists from the fields of molecular biology, microbiology, biochemistry and biotechnology who can provide flexible, intelligent and customer-oriented solutions to the needs of science and industry.
Our vision is to broaden the applications for stable isotope labeled biomolecules. We offer innovative and high quality products, developments and excellent product qualities at favorable prices, combined with a flexible, solution oriented service to our customer service.
Silantes was founded in 1998 by Dr. Hermann Heumann from the German Max-Planck-Institute of Biotechnology. He developed a new (meanwhile patended) method for the production of stable isotope labeled biomolecules based on chemolithoautotrophic bacteria (patent pending).
This technology exploits the fact that chemolithoautotrophic bacteria can metabolise inorganic carbon in a pathway similar to that of green plants. Chemolithoautotrophic bacteria combine the advantage of green plants of being able to assimilate CO2 with the advantage that bacteria are more productive and are also capable of expressing heterologous proteins.
The labeled chemolithoautotrophic bacteria cells are used as a factory to produce the stable isotope labeled biomolecules of choice. This pioneering technology provides an outstanding homogeneity of components labeled with stable isotopes, especially in the area of triple labeled (2H, 13C and 15N) biomolecules.
Silantes currently offers a wide variety of biomolecules labeled in any combination of the stable isotopes 2H, 13C and 15N:
- ribo-Nucleosidetriphosphates (rNTPs)
- desoxy-Nucleosidetriphosphates (dNTPs)
- Rich growth media for E. coli
- Rich growth media for yeast
- Amino Acids
- Bio-NMR standards (Ubiquitin)
- Mice feed for in vivo labelling
- 13C-Lys-specific labelled diet for SILAC
- 15N-uniform labelled diet for SILAM
Our company has now been in existence for more than 20 years. Its range of products is continually increasing. These include:
- labeled fly
- labeled zebra fish
- labeled mice
- labeled mice tissues
Silantes can also provide the following services tailored to individual customer needs:
- Oligonucleotide synthesis
- Phosphoramidites synthesis
- In-vitro synthesis of proteins
- Expression of stable isotope labeled proteins and peptides with our proprietary expression systems
- Fermentation service (E. coli)
- Silantes scientists will be happy to assist you in finding optimal solutions for your stable isotope applications.
Advantages for our customers
Silantes technology for in vivo enrichment of stable isotopes in biomolecules is vastly superior to established methods with respect to reliability, speed, quality, versatility and cost.
Silantes is a relatively young dynamic company with a highly motivated and flexible team eager to assist customers in finding customized solutions.
Our comprehensive range of services is unique world-wide.
We look forward to discussing your special applications with you and assisting you in finding optimal solutions.