Guanine

From: 750  plus VAT, plus delivery

Available in various isotopic labelings and/or quantities.

Description

– This product is in powder form

– Isotopic enrichment for all labelings except for U-2H: > 98 atom %

– Chemical purity > 95 %

Guanine is one of the four main nucleobases found in the nucleic acids DNA and RNA. The shape of guanine is complementary to cytosine both in DNA and RNA. Derivatives of guanine have a variety of roles in biochemistry such as energy sources in the form of GTP or carriers of signals in the cell. They also have functions in protein synthesis and as a chemical component of DNA and RNA.

References

Silantes nucleosides and nucleotides in scientific publications:

โ€ข Spada, F., Schiffers, S., Kirchner, A., Zhang, Y., Arista, G., Kosmatchev, O., Korytiakova, E., Rahimoff, R., Ebert, C., & Carell, T. (2020). Active turnover of genomic methylcytosine in pluripotent cells. Nature Chemical Biology, 16(12), 1411โ€“1419. https://doi.org/10.1038/s41589-020-0621-y

โ€ขLe, T. M., Poddar, S., Capri, J. R., Abt, E. R., Kim, W., Wei, L., Uong, N. T., Cheng, C. M., Braas, D., Nikanjam, M., Rix, P., Merkurjev, D., Zaretsky, J., Kornblum, H. I., Ribas, A., Herschman, H. R., Whitelegge, J., Faull, K. F., Donahue, T. R., . . . Radu, C. G. (2017). ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways. Nature Communications, 8(1). https://doi.org/10.1038/s41467-017-00221-3

โ€ข Hagelskamp, F., Borland, K., Ammann, G., & Kaiser, S. M. (2023). Temporal resolution of NAIL-MS of tRNA, rRNA and Poly-A RNA is overcome by actinomycin D. RSC Chemical Biology, 4(5), 354โ€“362. https://doi.org/10.1039/d2cb00243d

โ€ข Murakami, H., Horiba, R., Iwata, T., Miki, Y., Uno, B., Sakai, T., Kaneko, K., Ishihama, Y., Teshima, N., & Esaka, Y. (2018). Progress in a selective method for the determination of the acetaldehyde-derived DNA adducts by using HILIC-ESI-MS/MS. Talanta, 177, 12โ€“17. https://doi.org/10.1016/j.talanta.2017.09.055#

โ€ข Musheev, M. U., Schomacher, L., Basu, A., Han, D., Krebs, L., Scholz, C., & Niehrs, C. (2022b). Mammalian N1-adenosine PARylation is a reversible DNA modification. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-33731-w #

โ€ข Sachse, B., Meinl, W., Sommer, Y., Glatt, H., Seidel, A., & Monien, B. H. (2014). Bioactivation of food genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol by sulfotransferases from human, mouse and rat: a comparative study. Archives of Toxicology, 90(1), 137โ€“148. https://doi.org/10.1007/s00204-014-1392-6

โ€ข Leismann, J., Spagnuolo, M., Pradhan, M., Wacheul, L., Vu, M. A., Musheev, M., Mier, P., Andradeโ€Navarro, M. A., Graille, M., Niehrs, C., Lafontaine, D. L., & Roignant, J. (2020). The 18S ribosomal RNA m 6 A methyltransferase Mettl5 is required for normal walking behavior in Drosophila. EMBO Reports, 21(7). https://doi.org/10.15252/embr.201949443

โ€ข Koga, Y., Tsuchimoto, D., Hayashi, Y., Abolhassani, N., Yoneshima, Y., Sakumi, K., Nakanishi, H., Toyokuni, S., & Nakabeppu, Y. (2020). Neural stem cellโ€“specific ITPA deficiency causes neural depolarization and epilepsy. JCI Insight, 5(22). https://doi.org/10.1172/jci.insight.140229

โ€ข McManus, J., He, T., Gavigan, J., Marchand, G., Vougier, S., Bedel, O., Ferrari, P., Arrebola, R., Gillespy, T., Gregory, R. C., Licht, S., Cheng, H., Zhang, B., & Deng, G. (2018). A Robust Multiplex Mass Spectrometric Assay for Screening Small-Molecule Inhibitors of CD73 with Diverse Inhibition Modalities. SLAS DISCOVERY, 23(3), 264โ€“273. https://doi.org/10.1177/2472555217750386

โ€ข Stefano, J. E., Lord, D. M., Zhou, Y., Jaworski, J., Hopke, J., Travaline, T., Zhang, N., Wong, K., Lennon, A., He, T., Bric-Furlong, E., Cherrie, C., Magnay, T., Remy, E., Brondyk, W., Qiu, H., & Radoลกeviฤ‡, K. (2020). A highly potent CD73 biparatopic antibody blocks organization of the enzyme active site through dual mechanisms. Journal of Biological Chemistry, 295(52), 18379โ€“18389. https://doi.org/10.1074/jbc.ra120.012395

โ€ข LC-MS based Metabolomics – DTU Findit. (n.d.). https://findit.dtu.dk/en/catalog/586bd89c6c8183835e00009a

โ€ขNiu, C., Wang, X., Gao, Y., Qiao, X., Xie, J., Zhang, Y., Wang, D., & Dong, L. (2022). Accurate quantification of SARS-CoV-2 RNA by isotope dilution mass spectrometry and providing a correction of reverse transcription efficiency in droplet digital PCR. Analytical and Bioanalytical Chemistry, 414(23), 6771โ€“6777. https://doi.org/10.1007/s00216-022-04238-6

โ€ข Stefano, J. E., Lord, D. M., Zhou, Y., Jaworski, J., Hopke, J., Travaline, T., Zhang, N., Wong, K., Lennon, A., He, T., Bric-Furlong, E., Cherrie, C., Magnay, T., Remy, E., Brondyk, W., Qiu, H., & Radoลกeviฤ‡, K. (2020b). A highly potent CD73 biparatopic antibody blocks organization of the enzyme active site through dual mechanisms. Journal of Biological Chemistry, 295(52), 18379โ€“18389. https://doi.org/10.1074/jbc.ra120.012395

โ€ข McManus, J., He, T., Gavigan, J., Marchand, G., Vougier, S., Bedel, O., Ferrari, P., Arrebola, R., Gillespy, T., Gregory, R. C., Licht, S., Cheng, H., Zhang, B., & Deng, G. (2018b). A Robust Multiplex Mass Spectrometric Assay for Screening Small-Molecule Inhibitors of CD73 with Diverse Inhibition Modalities. SLAS DISCOVERY, 23(3), 264โ€“273. https://doi.org/10.1177/2472555217750386

โ€ข Fromme, T., Kleigrewe, K., Dunkel, A., Retzler, A., Li, Y., Maurer, S., Fischer, N., Diezko, R., Kanzleiter, T., Hirschberg, V., Hofmann, T., & Klingenspor, M. (2018). Degradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity. Molecular Metabolism, 8, 77โ€“85. https://doi.org/10.1016/j.molmet.2017.12.010

โ€ข Rahbar, S., Synold, T. W., Termini, J., & Hope, C. O. (2008, August 8). US20180207116A1 – Methods of quantifying n2-(1-carboxyethyl)-2โ€™-deoxy-guanosine (cedg) and synthesis of oligonucleotides containing cedg – Google Patents. https://patents.google.com/patent/US20180207116A1/en

โ€ข Kienhรถfer, S., Musheev, M. U., Stapf, U., Helm, M., Schomacher, L., Niehrs, C., & Schรคfer, A. (2015). GADD45a physically and functionally interacts with TET1. Differentiation, 90(1โ€“3), 59โ€“68. https://doi.org/10.1016/j.diff.2015.10.003

โ€ข Li, C., Li, Y., Wang, Y., Meng, R., Shi, X., Zhang, Y., Liang, N., Huang, H., Li, Y., Zhou, H., Xu, J., Xu, W., & Chen, H. (2023). The exotic thymidine modification 5-hydroxymethyluridine in dinoflagellateAmphidinium carterae. bioRxiv (Cold Spring Harbor Laboratory). https://doi.org/10.1101/2023.11.30.569493

โ€ข Dombi, E., Marinaki, T., Spingardi, P., Millar, V., Hadjichristou, N., Carver, J., Johnston, I. G., Fratter, C., & Poulton, J. (2024). Nucleoside supplements as treatments for mitochondrial DNA depletion syndrome. Frontiers in Cell and Developmental Biology, 12. https://doi.org/10.3389/fcell.2024.1260496